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Title: Noonan syndrome, metabolic syndrome and stroke-in-the-young: Coincidence, causal or contribution?
Authors: Jakris Eu-Ahsunthornwattana
Objoon Trachoo
Donniphat Dejsuphong
Atchara Tunteeratum
Kanoknan Srichan
Thanyachai Sura
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2010
Citation: Journal of the Medical Association of Thailand. Vol.93, No.9 (2010), 1084-1087
Abstract: A 34-year-old Thai woman developed acute left hemiparesis with dysarthria from subcortical infarction of the right MCA territory eighteen months after being diagnosed with Noonan syndrome, diabetes mellitus, dyslipidaemia, and hypertension. Further investigations suggested atherosclerosis as a cause. Modifying her risk factors was difficult, artly because of limited adherence. Three years later, she had another attack of ischaemic stroke in the same area. Unlike the three previously reported cases, the causation of strokes in this patient appeared to be a more 'complex' interaction between genetic defect and environment including possible subtle arterial abnormalities, metabolic risk factors, and mental insufficiency.
ISSN: 01252208
Appears in Collections:Scopus 2006-2010

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