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Title: Increased blood oxidative stress in amphetamine users
Authors: Piyarat Govitrapong
Parichart Boontem
Patcharee Kooncumchoo
Sirinthorn Pinweha
Jatuporn Namyen
Yupin Sanvarinda
Smith Vatanatunyakum
Mahidol University
Thanyarak hospital
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2010
Citation: Addiction Biology. Vol.15, No.1 (2010), 100-102
Abstract: Amphetamine derivatives have been shown to be a potential brain neurotoxin based on the production of free radicals that occurs after administration. The purpose of this study was to examine the lipid peroxidation and antioxidant enzymes in the blood of amphetamine users. The plasma lipid peroxidation was determined and reported as thiobarbituric acid reactive substance and was significantly increased (+21%), whereas the activities of the erythrocyte antioxidant enzymes glutathione peroxidase, catalase, and superoxide dismutase were significantly decreased (-32%, -14% and -31%, respectively) in amphetamine users. These results implicated the potential role of oxidative stress in amphetamine-induced neurotoxicity. © 2009 Society for the Study of Addiction.
ISSN: 13691600
Appears in Collections:Scopus 2006-2010

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