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Title: Therapeutic drug monitoring of lopinavir in human immunodeficiency virus-infected children receiving adult tablets
Authors: Thanyawee Puthanakit
Kulkanya Chokephaibulkit
Piyarat Suntarattiwong
Meena Gorowara
Nirun Vanprapar
Pimsiri Leawsrisuk
Tulathip Suwanlerk
Pitch Boonrak
Kiat Ruxrungtham
The HIV Netherlands Australia Thailand Research Collaboration
Chulalongkorn University
Mahidol University
Thailand Ministry of Public Health
Keywords: Medicine
Issue Date: 1-Jan-2010
Citation: Pediatric Infectious Disease Journal. Vol.29, No.1 (2010), 79-82
Abstract: Because of the lack of a lopinavir/ritonavir (LPV/r) pediatric formulation, 54 HIV-infected children were given generic LPV/r adult tablets. Of 54 children, 21 took cut pills to get the appropriate dose. The median (interquartile range) LPV trough serum concentration (Ctrough) was 6.7 (5.0-9.9) mg/L. All the children had Ctrough >1.0 mg/L and 96% had values >4.0 mg/L. LPV/r adult tablets can be used in children when it is necessary. © 2009 by Lippincott Williams & Wilkins.
ISSN: 15320987
Appears in Collections:Scopus 2006-2010

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