Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13
Authors: Ester C. Löwenberg
Prakaykaew Charunwatthana
Sophie Cohen
Bert Jan Van Den Born
Joost C.M. Meijers
Emran B. Yunus
Mahtab U. Hassan
Gofranul Hoque
Richard J. Maude
Forradee Nuchsongsin
Marcel Levi
Arjen M. Dondorp
Academic Medical Centre, University of Amsterdam
Mahidol University
Chittagong Medical College Hospital
Nuffield Department of Clinical Medicine
Keywords: Medicine
Issue Date: 1-Jan-2010
Citation: Thrombosis and Haemostasis. Vol.103, No.1 (2010), 181-187
Abstract: Severe falciparum malaria remains a major killer in tropical countries. Central in the pathophysiology is mechanical obstruction in the microcirculation caused by cytoadherence and sequestration of parasitized erythrocytes. However, the pathogenesis of many features complicating severe malaria, including coma, renal failure and thrombocytopenia, remains incompletely understood. These disease manifestations are also key features of thrombotic thrombocytopenic purpura, a life-threatening disease strongly associated with a deficiency of the von Willebrand factor (VWF) cleaving protease, ADAMTS13. We measured plasma ADAMTS13 activity, VWF antigen and VWF propeptide levels in 30 patients with severe falciparum malaria, 12 patients with uncomplicated falciparum malaria and 14 healthy Bangladeshi controls. In patients with severe malaria ADAMTS13 activity levels were markedly decreased in comparison to normal controls (mean [95%CI]: 23% [20-26] vs. 64% [55-72]) and VWF antigen and propeptide concentrations were significantly elevated (VWF antigen: 439% [396-481] vs. 64% [46-83]; VWF propeptide: 576% [481-671] vs. 69% [59-78]). In uncomplicated malaria VWF levels were also increased compared to healthy controls but ADAMTS13 activity was normal. The results suggest that decreased ADAMTS13 activity in combination with increased VWF concentrations may contribute to the complications in severe malaria. © Schattauer 2010.
ISSN: 03406245
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.