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Title: The Asia-Pacific consensus on ulcerative colitis
Authors: Choon Jin Ooi
Kwong Ming Fock
Govind K. Makharia
Khean Lee Goh
Khoon Lin Ling
Ida Hilmi
Wee Chian Lim
Thia Kelvin
Peter R. Gibson
Richard B. Gearry
Qin Ouyang
Jose Sollano
Sathaporn Manatsathit
Rungsun Rerknimitr
Shu Chen Wei
Wai Keung Leung
H. Janaka De Silva
Rupert Wl Leong
Singapore General Hospital
Changi General Hospital
All India Institute of Medical Sciences, New Delhi
University of Malaya
Tan Tock Seng Hospital
Monash University
University of Otago
West China Hospital of Sichuan University
University of Santo Tomas, Manila
Mahidol University
Chulalongkorn University
National Taiwan University
Chinese University of Hong Kong
University of Kelaniya
University of New South Wales (UNSW) Australia
Keywords: Medicine
Issue Date: 1-Jan-2010
Citation: Journal of Gastroenterology and Hepatology (Australia). Vol.25, No.3 (2010), 453-468
Abstract: Inflammatory bowel disease (IBD) is increasing in many parts of the Asia-Pacific region. There is a need to improve the awareness of IBD and develop diagnostic and management recommendations relevant to the region. This evidence-based consensus focuses on the definition, epidemiology and management of ulcerative colitis (UC) in Asia. A multi-disciplinary group developed the consensus statements, reviewed the relevant literature, and voted on them anonymously using the Delphi method. The finalized statements were reviewed to determine the level of consensus, evidence quality and strength of recommendation. Infectious colitis must be excluded prior to diagnosing UC. Typical histology and macroscopic extent of the disease seen in the West is found in the Asia-Pacific region. Ulcerative colitis is increasing in many parts of Asia with gender distribution and age of diagnosis similar to the West. Extra-intestinal manifestations including primary sclerosing cholangitis are rarer than in the West. Clinical stratification of disease severity guides management. In Japan, leukocytapheresis is a treatment option. Access to biologic agents remains limited due to high cost and concern over opportunistic infections. The high endemic rates of hepatitis B virus infection require stringent screening before initiating immune-suppressive agents. Vaccination and prophylactic therapies should be initiated on a case-by-case basis and in accordance with local practice. Colorectal cancer complicates chronic colitis. A recent increase in UC is reported in the Asia-Pacific region. These consensus statements aim to improve the recognition of UC and assist clinicians in its management with particular relevance to the region. © 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
ISSN: 14401746
Appears in Collections:Scopus 2006-2010

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