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dc.contributor.authorChoon Jin Ooien_US
dc.contributor.authorKwong Ming Focken_US
dc.contributor.authorGovind K. Makhariaen_US
dc.contributor.authorKhean Lee Gohen_US
dc.contributor.authorKhoon Lin Lingen_US
dc.contributor.authorIda Hilmien_US
dc.contributor.authorWee Chian Limen_US
dc.contributor.authorThia Kelvinen_US
dc.contributor.authorPeter R. Gibsonen_US
dc.contributor.authorRichard B. Gearryen_US
dc.contributor.authorQin Ouyangen_US
dc.contributor.authorJose Sollanoen_US
dc.contributor.authorSathaporn Manatsathiten_US
dc.contributor.authorRungsun Rerknimitren_US
dc.contributor.authorShu Chen Weien_US
dc.contributor.authorWai Keung Leungen_US
dc.contributor.authorH. Janaka De Silvaen_US
dc.contributor.authorRupert Wl Leongen_US
dc.contributor.otherSingapore General Hospitalen_US
dc.contributor.otherChangi General Hospitalen_US
dc.contributor.otherAll India Institute of Medical Sciences, New Delhien_US
dc.contributor.otherUniversity of Malayaen_US
dc.contributor.otherTan Tock Seng Hospitalen_US
dc.contributor.otherMonash Universityen_US
dc.contributor.otherUniversity of Otagoen_US
dc.contributor.otherWest China Hospital of Sichuan Universityen_US
dc.contributor.otherUniversity of Santo Tomas, Manilaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherNational Taiwan Universityen_US
dc.contributor.otherChinese University of Hong Kongen_US
dc.contributor.otherUniversity of Kelaniyaen_US
dc.contributor.otherUniversity of New South Wales (UNSW) Australiaen_US
dc.identifier.citationJournal of Gastroenterology and Hepatology (Australia). Vol.25, No.3 (2010), 453-468en_US
dc.description.abstractInflammatory bowel disease (IBD) is increasing in many parts of the Asia-Pacific region. There is a need to improve the awareness of IBD and develop diagnostic and management recommendations relevant to the region. This evidence-based consensus focuses on the definition, epidemiology and management of ulcerative colitis (UC) in Asia. A multi-disciplinary group developed the consensus statements, reviewed the relevant literature, and voted on them anonymously using the Delphi method. The finalized statements were reviewed to determine the level of consensus, evidence quality and strength of recommendation. Infectious colitis must be excluded prior to diagnosing UC. Typical histology and macroscopic extent of the disease seen in the West is found in the Asia-Pacific region. Ulcerative colitis is increasing in many parts of Asia with gender distribution and age of diagnosis similar to the West. Extra-intestinal manifestations including primary sclerosing cholangitis are rarer than in the West. Clinical stratification of disease severity guides management. In Japan, leukocytapheresis is a treatment option. Access to biologic agents remains limited due to high cost and concern over opportunistic infections. The high endemic rates of hepatitis B virus infection require stringent screening before initiating immune-suppressive agents. Vaccination and prophylactic therapies should be initiated on a case-by-case basis and in accordance with local practice. Colorectal cancer complicates chronic colitis. A recent increase in UC is reported in the Asia-Pacific region. These consensus statements aim to improve the recognition of UC and assist clinicians in its management with particular relevance to the region. © 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.en_US
dc.rightsMahidol Universityen_US
dc.titleThe Asia-Pacific consensus on ulcerative colitisen_US
Appears in Collections:Scopus 2006-2010

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