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Title: 17β-estradiol attenuates LPS-induced interleukin-8 production by human peripheral blood monocytes through estrogen receptor-αactivation
Authors: Nipapan Malisorn
Noppawan P. Morales
Yupin Sanvarinda
Payong Wanikiat
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Nov-2010
Citation: African Journal of Pharmacy and Pharmacology. Vol.4, No.11 (2010), 806-810
Abstract: Proper regulation of the immune response is essential for immune homeostasis. Several proinflammatory cytokines released from activated monocytes mediate inflammation, including interleukine-8 (IL-8) which recruits neutrophils to the site of inflammation. 17β-Estradiol (E2) has a direct role in the modulation of the innate immune function and mediates profound effects on immune function of the monocytes. The effects of 17β-E2 are mediated principally by two receptor subtypes, ER and ER; both are expressed in monocytes. The aim of this study was, therefore, to characterize the estrogen receptor subtypes that mediate the estrogen effects on LPS-activated IL-8 production by human peripheral blood monocytes. 17β-E2 and PPT attenuated the production of IL-8 by LPS-activated monocytes in a dose-dependent manner and these effects can be reversed by ICI182, 780. These results suggested a role of ER on the attenuating effect of 17β-E2 on IL-8 production by human peripheral blood monocytes. © 2010 Academic Journals.
ISSN: 19960816
Appears in Collections:Scopus 2006-2010

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