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Title: Immunodominant T-cell responses to dengue virus NS3 are associated with DHF
Authors: Thaneeya Duangchinda
Wanwisa Dejnirattisai
Sirijit Vasanawathana
Wannee Limpitikul
Nattaya Tangthawornchaikul
Prida Malasit
Juthathip Mongkolsapaya
Gavin Screaton
Hammersmith Hospital
Thailand National Center for Genetic Engineering and Biotechnology
Khon Kaen Regional Hospital
Songkhla Hospital
Mahidol University
Keywords: Multidisciplinary
Issue Date: 28-Sep-2010
Citation: Proceedings of the National Academy of Sciences of the United States of America. Vol.107, No.39 (2010), 16922-16927
Abstract: Dengue infections are increasing at an alarming rate in many tropical and subtropical countries, where epidemics can put health care systems under extreme pressure. The more severe infections lead to dengue hemorrhagic fever (DHF), which can be life threatening. A variety of viral and host factors have been associated with the severity ofdengue infections. Because secondarydengue infectionismore commonly associated withDHF than primary infections, the acquired immune response to dengue, both B cells and T cells have been implicated. In this study, we set out to study T-cell responses across the entire dengue virus proteome and to see whether these were related to disease severity in a cohort of dengue-infected children from Thailand. Robust responses were observed in most infected individuals against most viral proteins. Responses to NS3 were the most frequent, and there was a very strong association between the magnitude of the response and disease severity. Furthermore, in DHF, cytokine-high CD107a-negative cells predominated.
ISSN: 10916490
Appears in Collections:Scopus 2006-2010

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