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Title: Evolution of MRSA during hospital transmission and intercontinental spread
Authors: Simon R. Harris
Edward J. Feil
Matthew T.G. Holden
Michael A. Quail
Emma K. Nickerson
Narisara Chantratita
Susana Gardete
Ana Tavares
Nick Day
Jodi A. Lindsay
Jonathan D. Edgeworth
Hermínia De Lencastre
Julian Parkhill
Sharon J. Peacock
Stephen D. Bentley
Wellcome Trust Sanger Institute
University of Bath
Mahidol University
University of Cambridge
Instituto de Tecnologia Quimica e Biologica - Univesidade Nova de Lisboa
Rockefeller University
Nuffield Department of Clinical Medicine
St George's University of London
King's College London
Guy's and St Thomas' NHS Foundation Trust
Keywords: Multidisciplinary
Issue Date: 22-Jan-2010
Citation: Science. Vol.327, No.5964 (2010), 469-474
Abstract: Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a highthroughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.
ISSN: 10959203
Appears in Collections:Scopus 2006-2010

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