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Title: Transient, acquired glucose-6-phosphate dehydrogenase deficiency in Thai children with thyphoid fever
Authors: V. S. Tanphaichitr
V. Suvatte
C. Mahasandana
S. Tuchinda
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-1982
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.13, No.1 (1982), 105-109
Abstract: Seventy nine children with typhoid fever were studied, 45 were males and 34 were females. There were 9 out of 45 male patients (20%) who had definite G-6-PD deficiency of whom 3 had acute intravascular hemolysis. The rest of the patients had transient low enzyme activity during the first few weeks of their illness, with reticulocytopenia. Their G-6-PD activities rose up to normal levels later in the course of the disease while the reticulocytes were also increased. This study demonstrated that even in normal G-6-PD subjects, typhoid fever can cause a transient, acquired low G-6-PD level due to bone marrow suppression. It was suggested from this study that quantitative G-6-PD assay was more useful and sensitive than the screening method and that long term follow up is needed in the case that had unexplained low G-6-PD activity.
ISSN: 00383619
Appears in Collections:Scopus 1969-1990

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