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Authors: M. J. Warrell
Pravan Suntharasamai
Abha Sinhaseni
Rod Phanfung
J. C. Vincent-Falquet
Danai Bunnag
D. A. Warrell
Chaisin Viravan
Dusit Udomsakdi
C. Xueref
K. G. Nicholson
Tranakchit Harinasuta
Mahidol University
Nuffield Department of Clinical Medicine
Liverpool School of Tropical Medicine
Thai Red Cross Agency
Institut Merieux
MRC Clinical Research Centre
Keywords: Medicine
Issue Date: 6-Aug-1983
Citation: The Lancet. Vol.322, No.8345 (1983), 301-304
Abstract: Vaccine regimens using 0·1 ml human diploid cell strain vaccine (HDCSV) given intradermally (id) in single and multiple sites, or with aluminium hydroxide adjuvant given subcutaneously (sc), were compared with the regimens of HDCSV and Semple vaccine currently suggested by WHO. Some groups were also given human rabies-immune globulin (HRIG). Neutralising antibody titres were monitored for 3 months. Antibody was detected earliest in subjects given 0 ·1 ml HDCSV id at each of eight sites. The highest antibody titres from day 14 onwards were found after intramuscular (im) administration of HDCSV, but the multiple-site id regimen, which requires only one quarter of the volume of vaccine required for the im regimen, gave similar results, provided that a booster was given on day 91. This finding suggests that a treatment schedule based on this regimen would be suitable for post-exposure prophylaxis. Adjuvanted vaccine gave similar results to the same amount of antigen given id. Semple vaccine produced the lowest titres. HRIG, given at the high dose of 40 IU per kg, suppressed the antibody response to some of the regimens. © 1983.
ISSN: 01406736
Appears in Collections:Scopus 1969-1990

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