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dc.contributor.authorH. K. Toppozadaen_US
dc.contributor.authorS. Koetsawangen_US
dc.contributor.authorV. E. Aimakhuen_US
dc.contributor.authorT. Khanen_US
dc.contributor.authorA. Pretnar-Darovecen_US
dc.contributor.authorT. K. Chatterjeeen_US
dc.contributor.authorM. P. Molitor-Pefferen_US
dc.contributor.authorR. Apeloen_US
dc.contributor.authorR. Lichtenbergen_US
dc.contributor.authorP. G. Crosignanien_US
dc.contributor.authorJ. C. de Souzaen_US
dc.contributor.authorM. Garcia Huidubroen_US
dc.contributor.authorA. A. Haspelsen_US
dc.contributor.authorJ. Annusen_US
dc.contributor.authorG. Benaginaoen_US
dc.contributor.authorP. Diethelmen_US
dc.contributor.authorR. Grayen_US
dc.contributor.authorP. E. Hallen_US
dc.contributor.authorS. E. Holcken_US
dc.contributor.otherEl-Shatby University Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Ibadanen_US
dc.contributor.otherNational Research Institute of Fertility Controlen_US
dc.contributor.otherUniv. Hosp.en_US
dc.contributor.otherUniversity of Zambia School of Medicineen_US
dc.contributor.otherMouvement luxembourgeois pour le planning familialen_US
dc.contributor.otherUniversity of the Philippines Manilaen_US
dc.contributor.otherInstituto Nacional de la Nutricion Salvador Zubiranen_US
dc.contributor.otherUniversita degli Studi di Milanoen_US
dc.contributor.otherUniversidade Federal da Bahiaen_US
dc.contributor.otherHospital Jose Joaquin Aguirreen_US
dc.contributor.otherUtrecht Universityen_US
dc.contributor.otherOrganisation Mondiale de la Santeen_US
dc.identifier.citationContraception. Vol.28, No.1 (1983), 1-20en_US
dc.description.abstractFinal results are presented from a two-year WHO multinational comparative trial of three regimens: depot-medroxyprogesterone acetate (DMPA) given at 90-day intervals, norethisterone enantate (NET-EN) given at 60-day intervals for the entire study period (NET-EN (60-day)), and NET-EN given at 60-day intervals for six months and thereafter at 84-day intervals (NET-EN (84-day)). 1587 DMPA subjects were observed for 20,550 woman-months, 789 NET-EN (60-day) subjects were observed for 10,361 woman-months, and 796 NET-EN (84-day) subjects were observed for 10,331 woman-months. This clinical trial represents the largest clinical trial undertaken on injectable contraceptives. After two years, the pregnancy rate with NET-EN (84-day) was 1.4 (±0.6 S.E.) per 100 women, as compared with the two-year rates of 0.4 (±0.3 S.E.) per 100 women observed with DMPA and 0.4 (± 0.2 S.E.) with NET-EN (60-day). Both discontinuation rates for amenorrhea and the prevalence of amenorrhea lasting more than 90 days were significantly higher with DMPA than with either NET-EN regimen. Terminations for bleeding problems were similar with the three treatments, despite a better cyclic pattern for the first six months with the NET-EN regimens. The three treatments were comparable with respect to discontinuation rates for other medical or personal reasons, and for all reasons combined. For family planning programs, NET-EN (60-day) has the advantage of low pregnancy rates compared to NET-EN (84-day), and a schedule of administration that does not change. Both NET-EN regimens produce less amenorrhea than DMPA. However, the NET-EN (60-day) regimen has the logistic and economic disadvantage of requiring more frequent injections. All three injectable regimens compare favourably with oral contraceptives in terms of pregnancy and total continuation rates observed in clinical trial settings. © 1983.en_US
dc.rightsMahidol Universityen_US
dc.titleMultinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. Final report. Who special programme of research, development and research training in human reproductionen_US
Appears in Collections:Scopus 1969-1990

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