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Title: Stimulation of Ca<sup>2+</sup>uptake in the human liver fluke Opisthorchis viverrini by praziquantel
Authors: Pintip Ruenwongsa
Nongporn Hutadilok
Yongyuth Yuthavong
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 30-May-1983
Citation: Life Sciences. Vol.32, No.22 (1983), 2529-2534
Abstract: 45Ca2+uptake by the human liver fluke Opisthorchis viverrini is enhanced by praziquantel. The drug-induced45Ca2+uptake was dependent on the presence of Ca2+and was attenuated in the presence of 10 mM Mg2+. La3+and vanadate at concentration of 1mM partially reduced the amount of45Ca2+uptake into the liver fluke in response to praziquantel treatment. The stimulating effect of praziquantel was eliminated in the presence of 10 μM verapamil. These findings suggest that praziquantel increases the permeability of the liver fluke tegument to Ca2+probably by interfering with the mechanism that regulates Ca2+binding or trnasport across the tegumental membrane. © 1983.
ISSN: 00243205
Appears in Collections:Scopus 1969-1990

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