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Title: Studies on aristolochia III. isolation and biological evaluation of constituents of aristolochia indica roots for fertility-regulating activity<sup>1</sup>
Authors: Mohamed S. Ahmed
Sam S. Kang
Pathmanayaki Rajamahendran
Nuntavan Bunyapraphatsara
R. O.B. Wijesekera
Chun Tao Che
Donald P. Waller
A. S. Bingel
Annamarie Martin
David C. Lankin
Geoffrey A. Cordell
Djaja D. Soejarto
Harry H.S. Fong
Cairo University Faculty of Pharmacy
Seoul National University
University of Colombo
Mahidol University
United Nations Industrial Development Organization
University of Illinois Medical Center
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1984
Citation: Journal of Natural Products. Vol.47, No.2 (1984), 331-341
Abstract: ethanol extract of Aristolochia indica roots decreased fertility in both rats and hamsters when administered postcoitally (days 1-10 and 1-6, respectively). Petroleum ether (A), CHCl3(B), and aqueous (C) fractions, tested similarly in rats, were inactive and/or toxic. Partition of fraction B afforded non-acidic (D) and acidic (E) fractions. Savinin (1), isolated from fraction D and not previously reported from the Aristolochiaceae, was inactive when administered postcoitally to rats. Aristolochic acid-I (2), reported previously from A. indica and isolated from fraction E, was inactive when administered postcoitally to rats and toxic when administered postcoitally to hamsters. © 1984, American Chemical Society. All rights reserved.
ISSN: 15206025
Appears in Collections:Scopus 1969-1990

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