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Title: Mefloquine-pyrimethamine-sulfadoxine combination delays emergence of mefloquine resistant Plasmodium falciparum in continuous culture
Authors: P. Tan-Ariya
C. R. Brockelman
C. Menabandhu
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-1984
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.15, No.4 (1984), 531-535
Abstract: The efficacy of mefloquine against Plasmodium falciparum in continuous culture was studied. The development of mefloquine resistance in P. falciparum was significantly inhibited by a combination of mefloquine, pyrimethamine and sulfadoxine. By contrast, more resistant variants were selected in continuous culture without drug pressure or with pyrimethamine-sulfadoxine pressure. The most mefloquine resistant variants were selected by step-wise increases in mefloquine pressure.
ISSN: 00383619
Appears in Collections:Scopus 1969-1990

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