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|Title:||MULTI-SITE INTRADERMAL AND MULTI-SITE SUBCUTANEOUS RABIES VACCINATION: IMPROVED ECONOMICAL REGIMENS|
|Authors:||M. J. Warrell|
K. G. Nicholson
D. A. Warrell
J. C. Vincent-Falquet
Nuffield Department of Clinical Medicine
Thai Red Cross Agency
MRC Clinical Research Centre
|Citation:||The Lancet. Vol.323, No.8382 (1984), 874-876|
|Abstract:||Neutralising antibody responses to six post-exposure regimens of human diploid cell strain rabies vaccine with or without human rabies immune globulin (HRIG) were studied in 98 patients. The total amount of vaccine used was 22-34% of that required by conventional regimens. Vaccine was given at multiple sites intradermally or subcutaneously with or without adjuvant. Antibody was detectable within 7 days of the first dose in all subjects only in the groups given 0·1 ml intradermally at 8 sites. From day 14 onwards all groups showed an excellent antibody response; there was little difference between the various regimens. Suppression of the response to 8-site intradermal vaccination by a large dose of HRIG could be prevented by giving the second dose of vaccine on day 7 rather than day 14. © 1984.|
|Appears in Collections:||Scopus 1969-1990|
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