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Authors: M. J. Warrell
K. G. Nicholson
Pornthep Chanthavanich
Abha Sinhaseni
C. Xueref
Pravan Suntharasamai
D. A. Warrell
Chaisin Viravan
Rod Phanfung
J. C. Vincent-Falquet
Mahidol University
Nuffield Department of Clinical Medicine
Thai Red Cross Agency
Institut Merieux
MRC Clinical Research Centre
Keywords: Medicine
Issue Date: 21-Apr-1984
Citation: The Lancet. Vol.323, No.8382 (1984), 874-876
Abstract: Neutralising antibody responses to six post-exposure regimens of human diploid cell strain rabies vaccine with or without human rabies immune globulin (HRIG) were studied in 98 patients. The total amount of vaccine used was 22-34% of that required by conventional regimens. Vaccine was given at multiple sites intradermally or subcutaneously with or without adjuvant. Antibody was detectable within 7 days of the first dose in all subjects only in the groups given 0·1 ml intradermally at 8 sites. From day 14 onwards all groups showed an excellent antibody response; there was little difference between the various regimens. Suppression of the response to 8-site intradermal vaccination by a large dose of HRIG could be prevented by giving the second dose of vaccine on day 7 rather than day 14. © 1984.
ISSN: 01406736
Appears in Collections:Scopus 1969-1990

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