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Title: DNA cloning of plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope
Authors: Vincenzo Enea
Joan Ellis
Fidel Zavala
David E. Arnot
Achara Asavanich
Aoi Masuda
Isabella Quakyi
Ruth S. Nussenzweig
NYU Langone Medical Center
Mahidol University
New York University
University of Ghana
Keywords: Multidisciplinary
Issue Date: 1-Jan-1984
Citation: Science. Vol.225, No.4662 (1984), 628-630
Abstract: A clone of complementary DNA encoding the circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum has been isolated by screening an Escherichia coli complementary DNA library with a monoclonal antibody to the CS protein. The DNA sequence of the complementary DNA insert encodes a four-amino acid sequence: proline-asparagine-alanine-asparagine, tandemly repeated 23 times. The CS β-lactamase fusion protein specifically binds monoclonal antibodies to the CS protein and inhibits the binding of these antibodies to native Plasmodium falciparum CS protein. These findings provide a basis for the development of a vaccine against Plasmodium falciparum malaria.
ISSN: 00368075
Appears in Collections:Scopus 1969-1990

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