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|Title:||DNA cloning of plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope|
David E. Arnot
Ruth S. Nussenzweig
NYU Langone Medical Center
New York University
University of Ghana
|Citation:||Science. Vol.225, No.4662 (1984), 628-630|
|Abstract:||A clone of complementary DNA encoding the circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum has been isolated by screening an Escherichia coli complementary DNA library with a monoclonal antibody to the CS protein. The DNA sequence of the complementary DNA insert encodes a four-amino acid sequence: proline-asparagine-alanine-asparagine, tandemly repeated 23 times. The CS β-lactamase fusion protein specifically binds monoclonal antibodies to the CS protein and inhibits the binding of these antibodies to native Plasmodium falciparum CS protein. These findings provide a basis for the development of a vaccine against Plasmodium falciparum malaria.|
|Appears in Collections:||Scopus 1969-1990|
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