Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorThu, Aung Myinten_US
dc.contributor.authorKittiyod Poovorawanen_US
dc.contributor.authorChatporn Kittitrakulen_US
dc.contributor.authorApichart Nontpraserten_US
dc.contributor.authorNatthida Sriboonvorakulen_US
dc.contributor.authorWeerapong Phumratanaprapinen_US
dc.contributor.authorPisit Tangkijvanichen_US
dc.contributor.authorWattana Leowattanaen_US
dc.contributor.authorPolrat Wilairatanaen_US
dc.contributor.otherMahidol University. Faculty of Tropical Medicine. Department of Clinical Tropical Medicineen_US
dc.identifier.citationBMC Pharmacology and Toxicology. Vol.16, (2015), 38en_US
dc.description.abstractBackground: There is increasing concern about the potential for nephrotoxicity in patients with chronic hepatitis B (CHB) treated long-term with nucleotide analogs. Methods: We examined renal dysfunction and its associated risk factors in patients with CHB treated with antiviral regimens containing either nucleosides or nucleotide analogs. We undertook a retrospective cohort study from 2006 to 2014 at the Hospital for Tropical Diseases, Bangkok, Thailand, and analyzed the data of 102 patients with a median follow-up time of 44.5 months (range 4–101 months). Results: Seventy-three patients were treated with an antiviral regime containing a nucleoside analog, and 29 with a regime containing a nucleotide analog. Abnormally elevated serum creatinine concentration was observed in 12 patients (11.8 %) after 8 years of treatment. Thirty one percent of patients treated with nucleotide analogs had elevated serum creatinine levels and three of these patients (10.3 %) developed nephrotoxicity. In contrast, serum creatinine concentrations were elevated in three of the 73 patients treated with a nucleoside analog (4.1 %), and none developed nephrotoxicity. The incidence of renal dysfunction by the nucleotide analog regimen was cumulative, with 11.1, 21.0, 26.5 and 47.6 % of patients affected after 2, 4, 6 and 8 years, respectively. Univariate and multivariate analysis indicated that a nucleotide analog-based regimen significantly predicted renal dysfunction (odds ratio 10.5, 95 % confidence intervals 2.6–42.4, P <0.001). Conclusion: The long-term use of nucleotide analogs increased the risk of nephrotoxicity in patients with CHB. Thus, the regular assessment of renal function is recommended for all patients with CHB, particularly those treated with a nucleotide analog.en_US
dc.rightsMahidol Universityen_US
dc.subjectOpen Access articleen_US
dc.subjectAntiviral agentsen_US
dc.subjectChronic hepatitis Ben_US
dc.titleNephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailanden_US
dc.typeResearch Articleen_US
dc.rights.holderBioMed Centralen_US
Appears in Collections:TM-Article

Files in This Item:
File Description SizeFormat 
tm-ar- kittiyod-2015.pdf1.35 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.