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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/30873
Title: Induction of protective immunity against infection by Angiostrongylus cantonensis in rats
Authors: A. Dharmkrong-at
S. Sirisinha
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-1985
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.16, No.1 (1985), 31-40
Abstract: Attempts were made to induce acquired immunity against Angiostrongylus cantonensis infection by immunizing rats with somatic (L3S) and metabolic (L3ES) antigens from third-stage larvae and with somatic antigen from adult female worms (FACE) via either a combined intraperitoneal and oral (IP-OR-OR) or subcutaneous (SC-SC-SC) route. The most effective mean in inducing protection was the administration of L3S by the IP-OR-OR route, as judged from reduced mortality, prolonged survival periods and/or reduced worm burdens. Such a protocol reduced mortality to below 20% of the immunized controls. The worm burden of the L3S-immunized rats was only about 25% of the control value and the survival period was at least double. However, judging from gross morphology, the absence of stunted growth and unimpaired ficundity of the worms that developed into adult stage, it appears that those worms that survived had normal development. The latter observation is in contrast to that noted with FACE immunization which seemed to affect also the growth and development of worms that survived into adult stage.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0021849048&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/30873
ISSN: 00383619
Appears in Collections:Scopus 1969-1990

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