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Title: Protective effects of mangosteen extract on H<inf>2</inf>O <inf>2</inf>-induced cytotoxicity in SK-N-SH cells and scopolamine-induced memory impairment in mice
Authors: Jintana Sattayasai
Pongsatorn Chaonapan
Tarinee Arkaravichie
Rungtip Soi-ampornkul
Sarawut Junnu
Patcharakajee Charoensilp
Jutima Samer
Jiraporn Jantaravinid
Patarabutr Masaratana
Bhoom Suktitipat
Juthatip Manissorn
Visith Thongboonkerd
Neelobol Neungton
Primchanien Moongkarndi
Khon Kaen University
Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 27-Dec-2013
Citation: PLoS ONE. Vol.8, No.12 (2013)
Abstract: Mangosteen extracts (ME) contain high levels of polyphenolic compounds and antioxidant activity. Protective effects of ME against β-amyloid peptide (Aβ), induced cytotoxicity have been reported. Here, we further studied the protective effects of ME against oxidative stress induced by hydrogen peroxide (H2O2) and polychlorinated biphenyls (PCBs), and demonstrated the protection against memory impairment in mice. The cytoprotective effects of ME were measured as cell viability and the reduction in ROS activity. In SK-N-SH cell cultures, 200 ìg/ml ME could partially antagonize the effects of 150 or 300 μM H2O2 on cell viability, ROS level and caspase-3 activity. At 200, 400 or 800 μg/ml, ME reduced AChE activity of SK-N-SH cells to about 60% of the control. In vivo study, Morris water maze and passive avoidance tests were used to assess the memory of the animals. ME, especially at 100 mg/kg body weight, could improve the animal's memory and also antagonize the effect of scopolamine on memory. The increase in ROS level and caspase-3 activity in the brain of scopolamine-treated mice were antagonized by the ME treatment. The study demonstrated cytoprotective effects of ME against H2O2 and PCB-52 toxicity and having AChE inhibitory effect in cell culture. ME treatment in mice could attenuate scopolamine-induced memory deficit and oxidative stress in brain. © 2013 Sattayasai et al.
ISSN: 19326203
Appears in Collections:Scopus 2011-2015

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