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Title: Tropism of avian influenza a (H5N1) virus to mesenchymal stem cells and CD34<sup>+</sup> hematopoietic stem cells
Authors: Maytawan Thanunchai
Pumaree Kanrai
Suwimon Wiboon-ut
Pilaipan Puthavathana
Suradej Hongeng
Arunee Thitithanyanont
Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 10-Dec-2013
Citation: PLoS ONE. Vol.8, No.12 (2013)
Abstract: The presence of abnormal hematologic findings such as lymphopenia, thrombocytopenia, and pancytopenia were diagnosed in severe cases of avian influenza A H5N1. Whether direct viral dissemination to bone marrow (BM) cells causes this phenomenon remains elusive. We explore the susceptibility of the two stem cell types; hematopoietic stem cells (HSCs) and mesenchymal stromal cells (MSCs) isolated from human BM cells or cord blood, to infection with avian H5N1 viruses. For the first time, we demonstrated that the H5N1 virus could productively infect and induce cell death in both human stem cell types. In contrast, these activities were not observed upon human influenza virus infection. We also determined whether infection affects the immunomodulatory function of MSCs. We noted a consequent dysregulation of MSC-mediated immune modulation as observed by high cytokine and chemokine production in H5N1 infected MSCs and monocytes cocultures. These findings provide a better understanding of H5N1 pathogenesis in terms of broad tissue tropism and systemic spread. © 2013 Thanunchai et al.
ISSN: 19326203
Appears in Collections:Scopus 2011-2015

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