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Title: Broad-coverage molecular epidemiology of Orientia tsutsugamushi in Thailand
Authors: Patimaporn Wongprompitak
Wichittra Anukool
Ekkarat Wongsawat
Saowalak Silpasakorn
Veasna Duong
Philippe Buchy
Serge Morand
Roger Frutos
Pattama Ekpo
Yupin Suputtamongkol
Mahidol University
Institut Pasteur du Cambodge
Institut des Sciences de l'Evolution UMR 5554
CIRAD Centre de Recherche de Montpellier
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Apr-2013
Citation: Infection, Genetics and Evolution. Vol.15, (2013), 53-58
Abstract: Orientia tsutsugamushi, an obligate intracellular bacterium closely related to the genus Rickettsia, is the causative agent of scrub typhus, a major cause of febrile illness in rural areas of Asia-Pacific region. Scrub typhus is transmitted by the bite of infected mites of the genus Leptotrombidium. The region of the 56-kDa TSA gene spanning from variable domain I (VDI) to variable domain IV (VDIV) was sequenced and used for genotyping 77 O. tsutsugamushi samples from human patients confirmed with scrub typhus from 2001 to 2003 and 2009 to 2010 in different regions of Thailand. These sequences were also compared to previously published 56-kDa TSA sequences. Only 4 genotypes out of 8 previously reported in Thailand were identified, i.e. Karp, JG-v, TA763 and Kato, respectively. Two strains were not associated with known genotypes but were closely related to Taiwanese strains. The Karp genotype was confirmed as the predominant clade. The JG-v and TA763 genotypes, in contrast to other studies, also were found. The genotype TA716 was not found, except for one strain previously described. © 2011 Elsevier B.V.
ISSN: 15677257
Appears in Collections:Scopus 2011-2015

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