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Title: High Number of Previous Plasmodium falciparum Clinical Episodes Increases Risk of Future Episodes in a Sub-Group of Individuals
Authors: Cheikh Loucoubar
Laura Grange
Richard Paul
Augustin Huret
Adama Tall
Olivier Telle
Christian Roussilhon
Joseph Faye
Fatoumata Diene-Sarr
Jean François Trape
Odile Mercereau-Puijalon
Anavaj Sakuntabhai
Jean François Bureau
Institut Pasteur, Paris
CNRS Centre National de la Recherche Scientifique
Institut Pasteur de Dakar
Universite Paris Descartes
Ecole des hautes etudes en sante publique
Institute of Health and Science
Institut de Recherche pour le Developpement Dakar
Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 6-Feb-2013
Citation: PLoS ONE. Vol.8, No.2 (2013)
Abstract: There exists great disparity in the number of clinical P. falciparum episodes among children of the same age and living in similar conditions. The epidemiological determinants of such disparity are unclear. We used a data-mining approach to explore a nineteen-year longitudinal malaria cohort study dataset from Senegal and identify variables associated with increased risk of malaria episodes. These were then verified using classical statistics and replicated in a second cohort. In addition to age, we identified a novel high-risk group of children in whom the history of P. falciparum clinical episodes greatly increased risk of further episodes. Age and a high number of previous falciparum clinical episodes not only play major roles in explaining the risk of P. falciparum episodes but also are risk factors for different groups of people. Combined, they explain the majority of falciparum clinical attacks. Contrary to what is widely believed, clinical immunity to P. falciparum does not de facto occur following many P. falciparum clinical episodes. There exist a sub-group of children who suffer repeated clinical episodes. In addition to posing an important challenge for population stratification during clinical trials, this sub-group disproportionally contributes to the disease burden and may necessitate specific prevention and control measures. © 2013 Loucoubar et al.
ISSN: 19326203
Appears in Collections:Scopus 2011-2015

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