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Title: Influenza A(H1N1)pdm09-Associated Pneumonia Deaths in Thailand
Authors: Charatdao Bunthi
Somsak Thamthitiwat
Henry C. Baggett
Pasakorn Akarasewi
Ruchira Ruangchira-urai
Susan A. Maloney
Kumnuan Ungchusak
Centers for Disease Control (CDC), Thailand Field Station
Thailand Ministry of Public Health
Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 4-Feb-2013
Citation: PLoS ONE. Vol.8, No.2 (2013)
Abstract: Background: The first human infections with influenza A(H1N1)pdm09 virus were confirmed in April 2009. We describe the clinical and epidemiological characteristics of influenza A(H1N1)pdm09-associated pneumonia deaths in Thailand from May 2009-January 2010. Methods: We identified influenza A(H1N1)pdm09-associated pneumonia deaths from a national influenza surveillance system and performed detailed reviews of a subset. Results: Of 198 deaths reported, 49% were male and the median age was 37 years; 146 (73%) were 20-60 years. Among 90 deaths with records available for review, 46% had no identified risk factors for severe influenza. Eighty-eight patients (98%) received antiviral treatment, but only 16 (18%) initiated therapy within 48 hours of symptom onset. Conclusions: Most influenza A(H1N1)pdm09 pneumonia fatalities in Thailand occurred in adults aged 20-60 years. Nearly half lacked high-risk conditions. Antiviral treatment recommendations may be especially important early in a pandemic before vaccine is available. Treatment should be considered as soon as influenza is suspected.
ISSN: 19326203
Appears in Collections:Scopus 2011-2015

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