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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/31114
Title: In vitro inhibitory effects of moringa oleifera leaf extract and its major components on chemiluminescence and chemotactic activity of phagocytes
Authors: Boonyadist Vongsak
Wandee Gritsanapan
Yuvadee Wongkrajang
Ibrahim Jantan
Mahidol University
Universiti Kebangsaan Malaysia
Keywords: Agricultural and Biological Sciences;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2013
Citation: Natural Product Communications. Vol.8, No.11 (2013), 1559-1561
Abstract: The ethanol extract of Moringa oleifera Lam. leaves and its major constituents, crypto-chlorogenic acid, quercetin 3-O-glucoside and kaempferol 3-Oglucoside, were investigated on the respiratory burst of human whole blood and isolated human polymorphonuclear leukocytes (PMNs) using a luminol-based chemiluminescence assay. The chemotactic migration of PMNs was also investigated using the Boyden chamber technique. The ethanol extract demonstrated inhibitory activities on the oxidative burst and the chemotactic migration of PMNs. Quercetin 3-O-glucoside, crypto-chlorogenic acid, and kaempferol 3-Oglucoside, isolated from the extract, expressed relatively strong inhibitory activity on the oxidative burst of PMNs with IC50 values of 4.1, 6.7 and 7.0 μM, respectively, comparable with that of aspirin. They also demonstrated strong inhibition of chemotatic migration of PMNs with IC50 values of 9.5, 15.9 and 18.2 μM, respectively. The results suggest that M. oleifera leaves could modulate the immune response of human phagocytes, linking to its ethnopharmacological use as an anti-inflammatory agent. The immunomodulating activity of the plant was mainly due to its major components.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887466927&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/31114
ISSN: 15559475
1934578X
Appears in Collections:Scopus 2011-2015

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