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Title: Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome
Authors: Jih Jin Tsai
Kulkanya Chokephaibulkit
Po Chih Chen
Li Teh Liu
Hui Mien Hsiao
Yu Chih Lo
Guey Chuen Perng
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung Medical University
Mahidol University
Chung Hwa College of Medical Technology Taiwan
Emory University School of Medicine
National Cheng Kung University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 5-Dec-2013
Citation: Journal of Biomedical Science. Vol.20, No.1 (2013)
Abstract: Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making it an escalating global health problem of today. Dengue presents with spectrum of clinical manifestations, ranging from asymptomatic, undifferentiated mild fever, dengue fever (DF), to dengue hemorrhagic fever (DHF) with or without shock (DSS), a life-threatening illness characterized by plasma leakage due to increased vascular permeability. Currently, there are no antiviral modalities or vaccines available to treat and prevent dengue. Supportive care with close monitoring is the standard clinical practice. The mechanisms leading to DHF/DSS remains poorly understood. Multiple factors have been attributed to the pathological mechanism, but only a couple of these hypotheses are popular in scientific circles. The current discussion focuses on underappreciated factors, temperature, natural IgM, and endotoxin, which may be critical components playing roles in dengue pathogenesis. © 2013 Tsai et al.; licensee BioMed Central Ltd.
ISSN: 14230127
Appears in Collections:Scopus 2011-2015

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