Please use this identifier to cite or link to this item:
http://repository.li.mahidol.ac.th/dspace/handle/123456789/31175| Title: | Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities |
| Authors: | Ratchanok Pingaew Apilak Worachartcheewan Veda Prachayasittikul Supaluk Prachayasittikul Somsak Ruchirawat Virapong Prachayasittikul Srinakharinwirot University Mahidol University Chulabhorn Research Institute |
| Keywords: | Biochemistry, Genetics and Molecular Biology;Pharmacology, Toxicology and Pharmaceutics |
| Issue Date: | 1-Nov-2013 |
| Citation: | Letters in Drug Design and Discovery. Vol.10, No.9 (2013), 859-864 |
| Abstract: | Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds. ©2013 Bentham Science Publishers. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887864374&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/31175 |
| ISSN: | 1875628X 15701808 |
| Appears in Collections: | Scopus 2011-2015 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.