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Title: Transition metal complexes of 8-aminoquinoline-5-substituted uracils with antioxidative and cytotoxic activities
Authors: Ratchanok Pingaew
Apilak Worachartcheewan
Veda Prachayasittikul
Supaluk Prachayasittikul
Somsak Ruchirawat
Virapong Prachayasittikul
Srinakharinwirot University
Mahidol University
Chulabhorn Research Institute
Keywords: Biochemistry, Genetics and Molecular Biology;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Nov-2013
Citation: Letters in Drug Design and Discovery. Vol.10, No.9 (2013), 859-864
Abstract: Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds. ©2013 Bentham Science Publishers.
ISSN: 1875628X
Appears in Collections:Scopus 2011-2015

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