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dc.contributor.authorKiyoshi Kikuchien_US
dc.contributor.authorSalunya Tancharoenen_US
dc.contributor.authorTakashi Itoen_US
dc.contributor.authorYoko Morimoto-Yamashitaen_US
dc.contributor.authorNaoki Miuraen_US
dc.contributor.authorKo ichi Kawaharaen_US
dc.contributor.authorIkuro Maruyamaen_US
dc.contributor.authorYoshinaka Muraien_US
dc.contributor.authorEiichiro Tanakaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherKurume University School of Medicineen_US
dc.contributor.otherKagoshima University Faculty of Medicineen_US
dc.contributor.otherKagoshima Universityen_US
dc.contributor.otherOsaka Institute of Technologyen_US
dc.date.accessioned2018-10-19T04:36:04Z-
dc.date.available2018-10-19T04:36:04Z-
dc.date.issued2013-09-13en_US
dc.identifier.citationInternational Journal of Molecular Sciences. Vol.14, No.9 (2013), 18899-18924en_US
dc.identifier.issn14220067en_US
dc.identifier.issn16616596en_US
dc.identifier.other2-s2.0-84884185716en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884185716&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/31216-
dc.description.abstractStroke is a major cause of mortality and disability worldwide. The main cause of stroke is atherosclerosis, and the most common risk factor for atherosclerosis is hypertension. Therefore, antihypertensive treatments are recommended for the prevention of stroke. Three angiotensin receptor blockers (ARBs), telmisartan, irbesartan and candesartan, inhibit the expression of the receptor for advanced glycation end-products (RAGE), which is one of the pleiotropic effects of these drugs. High mobility group box 1 (HMGB1) is the ligand of RAGE, and has been recently identified as a lethal mediator of severe sepsis. HMGB1 is an intracellular protein, which acts as an inflammatory cytokine when released into the extracellular milieu. Extracellular HMGB1 causes multiple organ failure and contributes to the pathogenesis of hypertension, hyperlipidemia, diabetes mellitus, atherosclerosis, thrombosis, and stroke. This is the first review of the literature evaluating the potential of three ARBs for the HMGB1-RAGE axis on stroke therapy, including prevention and acute treatment. This review covers clinical and experimental studies conducted between 1976 and 2013. We propose that ARBs, which inhibit the HMGB1/RAGE axis, may offer a novel option for prevention and acute treatment of stroke. However, additional clinical studies are necessary to verify the efficacy of ARBs. © 2013 by the authors; licensee MDPI, Basel, Switzerland.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884185716&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemical Engineeringen_US
dc.subjectChemistryen_US
dc.subjectComputer Scienceen_US
dc.titlePotential of the angiotensin receptor blockers (ARBs) telmisartan, irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of strokeen_US
dc.typeReviewen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.3390/ijms140918899en_US
Appears in Collections:Scopus 2011-2015

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