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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/31235
Title: Long-term follow-up results of a multi-institutional phase 2 study of concurrent chemoradiation therapy for locally advanced cervical cancer in east and southeast Asia
Authors: Shingo Kato
Tatsuya Ohno
Kullathorn Thephamongkhol
Yaowalak Chansilpa
Jianping Cao
Xiaoting Xu
C. R Beena Devi
Tang Tieng Swee
Miriam J C Calaguas
Rey H. De Los Reyes
Chul Koo Cho
To Anh Dung
Nana Supriana
Dyah Erawati
Hideyuki Mizuno
Takashi Nakano
Hirohiko Tsujii
Saitama Medical University
National Institute of Radiological Sciences Chiba
Gunma University
Mahidol University
Soochow University
Hospital Umum Sarawak
St. Luke's Medical Center Quezon City
Jose R. Reyes Memorial Medical Center
Korea Cancer Center Hospital
National Cancer Institute
University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
Dr. Soetomo Hospital
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine;Physics and Astronomy
Issue Date: 1-Sep-2013
Citation: International Journal of Radiation Oncology Biology Physics. Vol.87, No.1 (2013), 100-105
Abstract: Purpose: To report the long-term survival and toxicity of a multi-institutional phase 2 study of concurrent chemoradiation therapy (CCRT) for locally advanced cervical cancer in east and southeast Asia. Methods and Materials: Ten institutions from 8 Asian countries participated in the study. Between April 2003 and March 2006, 120 patients (60 with bulky stage IIB and 60 with stage IIIB) were treated with CCRT. Radiation therapy consisted of pelvic external beam radiation therapy and either high-dose-rate or low-dose-rate intracavitary brachytherapy. Five cycles of weekly cisplatin (40 mg/m2) were administered during the course of radiation therapy. Treatment results were evaluated by the rates of local control, overall survival, and late toxicities. Results: Median follow-up was 63.7 months, and the follow-up rate at 5 years was 98%. The 5-year local control and overall survival rates for all patients were 76.8% and 55.1%, respectively. The 5-year rates of major late toxicities of the rectum and bladder were 7.9% and 0%, respectively. Conclusions: The long-term results have suggested that CCRT is safe and effective for patients with locally advanced cervical cancer in east and southeast Asia. However, further efforts are needed to improve overall survival. © 2013 Elsevier Inc.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84881344782&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/31235
ISSN: 1879355X
03603016
Appears in Collections:Scopus 2011-2015

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