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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/31275
Title: Preventive effects of Morus alba L. anthocyanins on diabetes in Zucker diabetic fatty rats
Authors: Ariya Sarikaphuti
Thamthiwat Nararatwanchai
Teruto Hashiguchi
Takashi Ito
Sita Thaworanunta
Kiyoshi Kikuchi
Yoko Oyama
Ikuro Maruyama
Salunya Tancharoen
Mae Fah Luang University
Kagoshima University Faculty of Medicine
Mahidol University
Kurume University School of Medicine
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 25-Jul-2013
Citation: Experimental and Therapeutic Medicine. Vol.6, No.3 (2013), 689-695
Abstract: The mulberry plant (Morus alba L.) contains abundant anthocyanins (ANCs), which are natural antioxidants. The aim of this study was to determine the ANC composition of Thai Morus alba L. fruits and to assess the effect of an ANC extract on blood glucose and insulin levels in male leptin receptor-deficient Zucker diabetic fatty (ZDF) rats. The major components of the ANC extract were identifed by high-performance liquid chromatography-electrospray ionization-mass spectrometry. ZDF and lean rats were treated with 125 or 250 mg ANCs/kg body weight, or 1% carboxy-methylcellulose (CMC) twice daily for 5 weeks. Neither ANC dose had an effect on body weight. Following 5 weeks of treatment, glucose levels were observed to increase from 105.5±8.7 to 396.25±21 mg/dl (P<0.0001) in the CMC-treated ZDF rats; however, the glucose levels were signifcantly lower in the rats treated with 125 or 250 mg/kg ANCs (228.25±45 and 131.75±10 mg/dl, respectively; P<0.001 versus CMC). The administration of 250 mg/kg ANCs normalized glucose levels in the ZDF rats towards those of the lean littermates. Insulin levels were decreased signifcantly in the ZDF rats treated with CMC or 125 mg/kg ANCs (P<0.0001), but not in the rats treated with 250 mg/kg ANCs. Histologically, 250 mg/kg ANCs was observed to prevent islet degeneration compared with the islets in CMC-treated rats. This study, demonstrated that ANCs extracted from Morus alba L. were well tolerated and exhibited effective anti-diabetic properties in ZDF rats. ANCs represent a promising class of therapeutic compounds that may be useful in the prevention of type 2 diabetes.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880484078&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/31275
ISSN: 17921015
17920981
Appears in Collections:Scopus 2011-2015

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