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dc.contributor.authorAriya Sarikaphutien_US
dc.contributor.authorThamthiwat Nararatwanchaien_US
dc.contributor.authorTeruto Hashiguchien_US
dc.contributor.authorTakashi Itoen_US
dc.contributor.authorSita Thaworanuntaen_US
dc.contributor.authorKiyoshi Kikuchien_US
dc.contributor.authorYoko Oyamaen_US
dc.contributor.authorIkuro Maruyamaen_US
dc.contributor.authorSalunya Tancharoenen_US
dc.contributor.otherMae Fah Luang Universityen_US
dc.contributor.otherKagoshima University Faculty of Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherKurume University School of Medicineen_US
dc.identifier.citationExperimental and Therapeutic Medicine. Vol.6, No.3 (2013), 689-695en_US
dc.description.abstractThe mulberry plant (Morus alba L.) contains abundant anthocyanins (ANCs), which are natural antioxidants. The aim of this study was to determine the ANC composition of Thai Morus alba L. fruits and to assess the effect of an ANC extract on blood glucose and insulin levels in male leptin receptor-deficient Zucker diabetic fatty (ZDF) rats. The major components of the ANC extract were identifed by high-performance liquid chromatography-electrospray ionization-mass spectrometry. ZDF and lean rats were treated with 125 or 250 mg ANCs/kg body weight, or 1% carboxy-methylcellulose (CMC) twice daily for 5 weeks. Neither ANC dose had an effect on body weight. Following 5 weeks of treatment, glucose levels were observed to increase from 105.5±8.7 to 396.25±21 mg/dl (P<0.0001) in the CMC-treated ZDF rats; however, the glucose levels were signifcantly lower in the rats treated with 125 or 250 mg/kg ANCs (228.25±45 and 131.75±10 mg/dl, respectively; P<0.001 versus CMC). The administration of 250 mg/kg ANCs normalized glucose levels in the ZDF rats towards those of the lean littermates. Insulin levels were decreased signifcantly in the ZDF rats treated with CMC or 125 mg/kg ANCs (P<0.0001), but not in the rats treated with 250 mg/kg ANCs. Histologically, 250 mg/kg ANCs was observed to prevent islet degeneration compared with the islets in CMC-treated rats. This study, demonstrated that ANCs extracted from Morus alba L. were well tolerated and exhibited effective anti-diabetic properties in ZDF rats. ANCs represent a promising class of therapeutic compounds that may be useful in the prevention of type 2 diabetes.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titlePreventive effects of Morus alba L. anthocyanins on diabetes in Zucker diabetic fatty ratsen_US
Appears in Collections:Scopus 2011-2015

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