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Title: Association between inflammatory marker, environmental lead exposure, and glutathione S-transferase gene
Authors: Jintana Sirivarasai
Winai Wananukul
Sming Kaojarern
Suwannee Chanprasertyothin
Nisakron Thongmung
Wipa Ratanachaiwong
Thanyachai Sura
Piyamit Sritara
Mahidol University
Health Office
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 11-Mar-2013
Citation: BioMed Research International. Vol.2013, (2013)
Abstract: A number of studies suggested that lead is related to the induction of oxidative stress, and alteration of immune response. In addition, modifying these toxic effects varied partly by GST polymorphism. The objectives of this study were to assess the association between the lead-induced alteration in serum hs-CRP, with GSTM1, GSTT1, and GSTP1 Val105Ile genetic variations and the health consequence from environmental lead exposure. The 924 blood samples were analyzed for blood lead, CRP, and genotyping of three genes with real-time PCR. Means of blood lead and serum hs-CRP were 5.45 g/dL and 2.07 mg/L. Both CRP and systolic blood pressure levels were significantly higher for individuals with blood lead in quartile 4 (6.48-24.63 g/dL) compared with those in quartile 1 (1.23-3.47 g/dL, P<0.01). In particular, in men with blood lead >6.47 g/dL the adjusted odds ratio (OR) of CRP levels for individuals with GSTP1 variants allele, GSTM1 null, GSTT1 null, double-null GSTM1, and GSTT1 compared with wild-type allele was 1.46 (95% CI; 1.05-2.20), 1.32 (95% CI; 1.03-1.69), 1.65 (95% CI; 1.17-2.35), and 1.98 (95% CI; 1.47-2.55), respectively. Our findings suggested that lead exposure is associated with adverse changes in inflammatory marker and SBP. GST polymorphisms are among the genetic determinants related to lead-induced inflammatory response. © 2013 Jintana Sirivarasai et al.
ISSN: 23146141
Appears in Collections:Scopus 2011-2015

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