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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/31374
Title: 16<sup>th</sup>IHIW: Anti-HLA alloantibodies of the of IgA isotype in re-transplant candidates
Authors: M. L. Arnold
F. M. Heinemann
P. Horn
M. Ziemann
N. Lachmann
A. Mühlbacher
A. Dick
A. Ender
D. Thammanichanond
G. F. Fischer
S. Schaub
M. Hallensleben
J. Mytilineos
W. E. Hitzler
C. Seidl
I. I.N. Doxiadis
B. M. Spriewald
Friedrich-Alexander-Universität Erlangen-Nürnberg
Universitats Klinikum Essen und Medizinische Fakultat
Universitatsklinikum Schleswig-Holstein Campus Lubeck
Charité – Universitätsmedizin Berlin
University Hospital Innsbruck
Klinikum der Universitat Munchen
Klinikum Stuttgart Katharinenhospital
Mahidol University
Medizinische Universitat Wien
Universitatsspital Basel
Medizinische Hochschule Hannover (MHH)
Universitatsklinikum Ulm
Klinikum der Johannes-Gutenberg-Universitat und Fachbereich Medizin
Institute for Transfusion Medicine and Immunohaematology
Leiden University Medical Center - LUMC
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Feb-2013
Citation: International Journal of Immunogenetics. Vol.40, No.1 (2013), 17-20
Abstract: In this multicentre study, sera from 803 retransplant candidates, including 775 kidney transplant recipients, were analysed with regard to the presence and specificity of anti-HLA alloantibodies of the IgA isotype using a modified microsphere-based platform. Of the kidney recipients, nearly one-third (n = 237, 31%) had IgA alloantibodies. Mostly, these antibodies were found in sera that also harboured IgG alloantibodies that could be found in a total of 572 (74%) of patients. Interestingly, IgA anti-HLA antibodies were preferentially targeting HLA class I antigens in contrast to those of the IgG isotype, which targeted mostly both HLA class I and II antigens. Donor specificity of the IgA alloantibodies could be established for over half of the 237 patients with IgA alloantibodies (n = 124, 52%). A further 58 patients had specificities against HLA-C or HLA-DP, for which no information regarding donor typing was available. In summary, these data showed in a large cohort of retransplant candidates that IgA alloantibodies occur in about one-third of patients, about half of these antibodies being donor specific. © 2012 Blackwell Publishing Ltd.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84872264921&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/31374
ISSN: 1744313X
17443121
Appears in Collections:Scopus 2011-2015

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