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dc.contributor.authorPissared Khuituanen_US
dc.contributor.authorKannikar Wongdeeen_US
dc.contributor.authorWalailuk Jantarajiten_US
dc.contributor.authorPanan Suntornsaratoonen_US
dc.contributor.authorNateetip Krishnamraen_US
dc.contributor.authorNarattaphol Charoenphandhuen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherBurapha Universityen_US
dc.date.accessioned2018-10-19T04:42:57Z-
dc.date.available2018-10-19T04:42:57Z-
dc.date.issued2013-01-01en_US
dc.identifier.citationArchives of Biochemistry and Biophysics. Vol.536, No.1 (2013), 46-52en_US
dc.identifier.issn10960384en_US
dc.identifier.issn00039861en_US
dc.identifier.other2-s2.0-84879234328en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879234328&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/31390-
dc.description.abstractThe calciotropic hormone 1,25-dihydroxyvitamin D3[1,25(OH)2D3] has been known to stimulate intestinal calcium transport via both transcellular and paracellular pathways. Recently, we reported that the 1,25(OH)2D3-enhanced calcium transport in the mouse duodenum could be abolished by fibroblast growth factor (FGF)-23, but the targeted calcium transport pathway has been elusive. Herein, the 1,25(OH)2D3-enhanced calcium transport was markedly inhibited by FGF-23 and inhibitors of the basolateral calcium transporters, NCX1 and PMCA1b, suggesting the negative effect of FGF-23 on the transcellular calcium transport. Similar results could be observed in the intestinal epithelium-like Caco-2 monolayer. Although the Arrhenius plot indicated that FGF-23 decreased the potential barrier (e.g., activation energy) of the paracellular calcium movement, FGF-23 was found to modestly decrease the 1,25(OH)2D3-enhanced paracellular calcium transport and calcium permeability. Moreover, FGF-23 affected the 1,25(OH)2D3-induced change in duodenal water permeability as determined by tritiated water, but both 1,25(OH)2D3and FGF-23 were without effects on the transepithelial fluxes of paracellular markers,3H-mannitol and14C-polyethylene glycol. It could be concluded that FGF-23 diminished the 1,25(OH)2D3-enhanced calcium absorption through the transcellular and paracellular pathways. Our findings have thus corroborated the presence of a bone-kidney-intestinal axis of FGF-23/vitamin D system in the regulation of calcium homeostasis. © 2013 Elsevier Inc. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84879234328&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleFibroblast growth factor-23 negates 1,25(OH)<inf>2</inf>D<inf>3</inf>-induced intestinal calcium transport by reducing the transcellular and paracellular calcium fluxesen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/j.abb.2013.05.009en_US
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