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Title: Vascular endothelial growth factor -634G/C polymorphism is associated with increased breast cancer risk and aggressiveness
Authors: Doonyapat Sa-Nguanraksa
Tuenjai Chuangsuwanich
Tawatchai Pongpruttipan
Tanawan Kummalue
Supakorn Rojananin
Adune Ratanawichhitrasin
Poramaporn Prasarttong-Osoth
Suebwong Chuthatisith
Pongthep Pisarnturakit
Waraporn Aeumrithaicharoenchok
Pradit Rushatamukayanunt
Visnu Lohsiriwat
Mongkol Boonsripitayanon
Prida Malasit
Pornchai O'Charoenrat
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2013
Citation: Molecular Medicine Reports. Vol.8, No.4 (2013), 1242-1250
Abstract: Polymorphisms in the promoter and 5' untranslated region of vascular endothelial growth factor (VEGF) have been associated with VEGF levels. To investigate the role of VEGF polymorphisms in breast cancer, the VEGF -2578C/A, -1498C/T, -1154G/A and -634G/C polymorphisms were genotyped in 483 breast cancer patients and 524 healthy controls. VEGF mRNA levels in breast cancer tissue were determined using semi-quantitative RT-PCR. The genotypes, C and -634C/C, were associated with an increased risk for breast cancer when compared with the -634G/G genotype. The VEGF C-634C genotype was associated with tumor size 20 mm, perineural invasion and stage II-IV. Individuals with -634C had lower disease-free survival. Patients with the VEGF -634C/C genotype exhibited the highest VEGF mRNA levels. High VEGF mRNA expression correlated with tumor size 20 mm, presence of lymphovascular invasion and axillary nodal metastasis. These observations suggested that VEGF -634G/C polymorphisms have a significant role in breast cancer susceptibility and aggressiveness.
ISSN: 17913004
Appears in Collections:Scopus 2011-2015

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