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Title: Decreased nitrite levels in erythrocytes of children with β-thalassemia/hemoglobin e
Authors: Thitiwat Suvachananonda
Amara Wankham
Sirada Srihirun
Pansakorn Tanratana
Supeenun Unchern
Suthat Fucharoen
Ampaiwan Chuansumrit
Nongnuch Sirachainan
Nathawut Sibmooh
Mahidol University
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2013
Citation: Nitric Oxide - Biology and Chemistry. Vol.33, (2013), 1-5
Abstract: Nitrite anion is bioactive nitric oxide (NO) species circulating in blood, and represents theNObioavailability and endothelial function. In this study, we aimed to investigate the nitrite levels and the correlation with hemolysis and severity in β-thalassemia/hemoglobin E (β-thal/HbE). 38 Children (12.0 ± 1.9 years of age) with a diagnosis of mild, moderate and severe β-thalassemia were enrolled in the study. The blood nitrite levels and potential plasma NO consumption were measured by the chemiluminescence method. The nitrite levels in whole blood and erythrocytes of the severe thalassemia subjects were lower than those of the control subjects. At day 7 after transfusion of packed erythrocytes, the nitrite levels in erythrocytes increased. The plasma hemoglobin and NO consumption increased in the severe thalassemia subjects. The nitrite levels in erythrocytes inversely correlated with plasma hemoglobin, lactate dehydrogenase activity, potential NO consumption, and lipid peroxidation. Our studies demonstrate the decreased NO bioavailability in thalassemia, which could result from endothelial dysfunction, the increased potential NO consumption in plasma by cell-free hemoglobin and oxidative stress. © 2013 Elsevier Inc. All rights reserved.
ISSN: 10898611
Appears in Collections:Scopus 2011-2015

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