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Title: New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Authors: Momoko Horikoshi
Hanieh Yaghootkar
Dennis O. Mook-Kanamori
Ulla Sovio
H. Rob Taal
Branwen J. Hennig
Jonathan P. Bradfield
Beate St Pourcain
David M. Evans
Pimphen Charoen
Marika Kaakinen
Diana L. Cousminer
Terho Lehtimäki
Eskil Kreiner-Møller
Nicole M. Warrington
Mariona Bustamante
Bjarke Feenstra
Diane J. Berry
Elisabeth Thiering
Thiemo Pfab
Sheila J. Barton
Beverley M. Shields
Marjan Kerkhof
Elisabeth M. Van Leeuwen
Anthony J. Fulford
Zoltán Kutalik
Jing Hua Zhao
Marcel Den Hoed
Anubha Mahajan
Virpi Lindi
Liang Kee Goh
Jouke Jan Hottenga
Ying Wu
Olli T. Raitakari
Marie N. Harder
Aline Meirhaeghe
Ioanna Ntalla
Rany M. Salem
Karen A. Jameson
Kaixin Zhou
Dorota M. Monies
Vasiliki Lagou
Mirna Kirin
Jani Heikkinen
Linda S. Adair
Fowzan S. Alkuraya
Ali Al-Odaib
Philippe Amouyel
Ehm Astrid Andersson
Amanda J. Bennett
Alexandra I.F. Blakemore
Jessica L. Buxton
Jean Dallongeville
Shikta Das
Eco J.C. De Geus
Xavier Estivill
Claudia Flexeder
Philippe Froguel
Frank Geller
University of Oxford
Wellcome Trust Centre for Human Genetics
University of Exeter
Erasmus University Medical Center
Weill Cornell Medicine-Qatar
Imperial College London
London School of Hygiene & Tropical Medicine
Medical Research Council
Medical Research Council Laboratories Gambia
The Children's Hospital of Philadelphia
University of Bristol
Mahidol University
Oulun Yliopisto
Helsingin Yliopisto
Tampereen Yliopisto
University Hospital of Tampere
University of Copenhagen, Faculty of Health Sciences
Copenhagen University Hospital
University of Western Australia Faculty of Medicine and Dentistry
Centre de Recerca en Epidemiologia Ambiental, Barcelona
Hospital del Mar
CIBER Epidemiologia Y Salud Publica
Centro de Regulacion Genomica
Statens Serum Institut
UCL Institute of Child Health
Helmholtz Center Munich German Research Center for Environmental Health
Charité – Universitätsmedizin Berlin
Universitat Potsdam
University of Southampton
University of Groningen, University Medical Center Groningen
Universitat Lausanne Schweiz
Swiss Institute of Bioinformatics
Addenbrooke's Hospital
Ita-Suomen yliopisto
Duke-NUS Graduate Medical School Singapore
National University of Singapore
Vrije Universiteit Amsterdam
The University of North Carolina at Chapel Hill
Turun yliopisto
Institut Pasteur Lille
University of Lille
Universite Lille 2 Droit et Sante
Harokopio University
Children's Hospital Boston
Broad Institute
Harvard Medical School
University of Dundee
King Faisal Specialist Hospital and Research Centre
University of Edinburgh
King Khaled Eye Specialist Hospital
Alfaisal University
Universitat Pompeu Fabra
Hammersmith Hospital
Southampton University Hospitals NHS Trust
Lille Inflammation Research International Center
Faculty of Health Sciences, University of Southern Denmark
Centre for Medical Systems Biology
Amtssygehuset i Glostrup
Kobenhavns Universitet
University of Athens Medical School
Universitat Leipzig
Medizinische Hochschule Hannover (MHH)
Northwestern University
University of Groningen
Klinikum der Universitat Munchen
Steno Diabetes Center
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2013
Citation: Nature Genetics. Vol.45, No.1 (2013), 76-82
Abstract: Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. © 2013 Nature America, Inc. All rights reserved.
ISSN: 15461718
Appears in Collections:Scopus 2011-2015

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