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Title: Bioimaging of copper deposition in Wilson's diseases mouse liver by laser ablation inductively coupled plasma mass spectrometry imaging (LA-ICP-MSI)
Authors: M. M. Pornwilard
Uta Merle
Ralf Weiskirchen
J. Sabine Becker
Forschungszentrum Jülich (FZJ)
Medizinische Fakultat und Universitats Klinikum Aachen
Mahidol University
Universitatsklinikum Heidelberg
Keywords: Chemistry;Physics and Astronomy
Issue Date: 1-Aug-2013
Citation: International Journal of Mass Spectrometry. Vol.354-355, (2013), 281-287
Abstract: Unbalance of metals play an important role in the development of liver diseases. Wilson's disease for example is an autosomal recessive disorder in which the liver does not release copper into bile and resulting metal buildup leads to organ damage and liver failure. Laser ablation inductively coupled plasma mass spectrometry imaging (LA-ICP-MSI) is an established analytical technique for the determination of trace metals in biological tissue. This work demonstrates a new application of LA-ICP-MSI of trace metal imaging (Mn, Fe, Cu, and Zn) to study Wilson's disease in mouse liver tissue (vs. control sections). The quantification of tissue trace metals was performed using in-house produced tissue standards from murine brain with well-defined element concentrations. The results show that the average concentrations of Mn in control (0.7 μg g-1) and Wilson's disease liver samples (0.6 μg g-1) were not different. In contrast, Fe, Cu, and Zn in Wilson's disease liver samples (80 μg g-1for Fe, 143 μg g-1for Cu, and 32 μg g-1for Zn) were found significantly higher than in control tissue samples (41 μg g-1for Fe, 4 μg g-1for Cu, and 18 μg g-1for Zn). © 2013 Elsevier B.V. All rights reserved.
ISSN: 13873806
Appears in Collections:Scopus 2011-2015

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