Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/31547
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNuttavut Kosemen_US
dc.contributor.authorKazuhiro Ichikawaen_US
dc.contributor.authorHideo Utsumien_US
dc.contributor.authorPrimchanien Moongkarndien_US
dc.contributor.otherKyushu Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-10-19T04:48:44Z-
dc.date.available2018-10-19T04:48:44Z-
dc.date.issued2013-04-01en_US
dc.identifier.citationJournal of Natural Medicines. Vol.67, No.2 (2013), 255-263en_US
dc.identifier.issn18610293en_US
dc.identifier.issn13403443en_US
dc.identifier.other2-s2.0-84878249790en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878249790&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/31547-
dc.description.abstractMangosteen (Garcinia mangostana) has been widely used in the traditional medicine of Thailand to treat various ailments, especially diseases of the digestive system and infections. Many reports show antiproliferation of crude extracts and active constituents from mangosteen against many cancer cell lines. Therefore, the current study is proposed to demonstrate in vivo evidence on the antitumor activity of mangosteen. Crude methanolic extract (CME) from mangosteen pericarp including 25.19 % α-mangostin as an active xanthone was used in this study. The inhibition on tumor cell proliferation of CME was preliminarily evaluated against the murine colon cancer cell line NL-17 with an IC50value of 17 and 84 μg/ml based on WST-1 and LDH assays, respectively. The safety dose for animal application was assessed by in vivo toxicity studies using female BALB/c mice. Acute toxicity showed an LD50value and approximate lethal dose at 1,000 mg/kg, whereas the suitable dose for short-term study should be ≤200 mg/kg. The effective dose for antitumor activity of CME was found to be between 100 and 200 mg/kg, with a tumor size reduction of 50-70 %. Histological staining clearly illustrated a decrease of tumor cell density in the footpad in a dose-dependent manner. The median survival time and life span significantly increased in tumor-bearing mice with CME treatment. This study suggests that CME possesses a powerful antitumor activity. Therefore, it is worth undertaking further investigation to identify active compounds and obtain a deeper understanding of their mechanism, in order to acquire novel effective anticancer drugs. © 2012 The Japanese Society of Pharmacognosy and Springer.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878249790&origin=inwarden_US
dc.subjectChemistryen_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleIn vivo toxicity and antitumor activity of mangosteen extracten_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1007/s11418-012-0673-8en_US
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.