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|Title:||Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs|
|Keywords:||Chemistry;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Chemical and Pharmaceutical Bulletin. Vol.61, No.2 (2013), 194-203|
|Abstract:||A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL. © 2013 The Pharmaceutical Society of Japan.|
|Appears in Collections:||Scopus 2011-2015|
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