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Title: The effect of vitamin D status on pediatric asthma at a University Hospital, Thailand
Authors: Wijittra Krobtrakulchai
Jittima Praikanahok
Nualanong Visitsunthorn
Pakit Vichyanond
Kotchamol Manonukul
Busadee Pratumvinit
Orathai Jirapongsananuruk
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 22-Oct-2013
Citation: Allergy, Asthma and Immunology Research. Vol.5, No.5 (2013), 289-294
Abstract: In the USA and Europe, hypovitaminosis D is associated with increased asthma severity, emergency department (ED) visit, and impaired pulmonary function in asthmatic patients. However, in tropical countries, data on the effect of vitamin D status on asthma is limited. This study evaluates the relationship between vitamin D status and the level of asthma control as well as other asthmatic parameters. Methods: Asthmatic children were evaluated for serum 25-hydroxyvitamin D, pulmonary function tests, a skin prick test, and the level of asthma control. Results: A total of 125 asthmatic children were recruited (boys, 66.4%). Their mean age±SD was 10.8±3.0 years. Vitamin D statuses were: deficiency (<20 ng/mL) in 19.2% of the patients, insufficiency (20-30 ng/mL) in 44.8%, and sufficiency (>30 ng/mL) in 36%. The vitamin D levels were 25.9±9.4 ng/mL in uncontrolled patients, 29.2±8.6 ng/mL in partly controlled patients, and 27.9±8.0 ng/mL in controlled patients (P > 0.05). There were no significant differences in pulmonary function, asthma exacerbation, inhaled-corticosteroid (ICS) dose, anti-inflammatory drugs, or ED visit or hospitalization between different vitamin D statuses. Vitamin D deficiency patients were older and had a delayed onset of asthma than insufficiency or sufficiency patients. There was no significant correlation between serum vitamin D and pulmonary function/doses of ICS. Conclusions: High prevalences of vitamin D deficiency and insufficiency were found in asthmatic children in Thailand; however, there was no significant relationship between vitamin D status and the level of asthma control or other asthma parameters. © The Korean Academy of Asthma, Allergy and Clinical Immunology.
ISSN: 20927363
Appears in Collections:Scopus 2011-2015

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