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Title: Short report: Molecular confirmation of co-infection by pathogenic leptospira spp. and orientia tsutsugamushi in patients with acute febrile illness in Thailand
Authors: Piengchan Sonthayanon
Wirongrong Chierakul
Vanaporn Wuthiekanun
Direk Limmathurotsakul
Premjit Amornchai
Lee D. Smythe
Nicholas P. Day
Sharon J. Peacock
Mahidol University
Queensland Health
Nuffield Department of Clinical Medicine
University of Cambridge
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Oct-2013
Citation: American Journal of Tropical Medicine and Hygiene. Vol.89, No.4 (2013), 797-799
Abstract: Leptospirosis and scrub typhus are major causes of acute febrile illness in rural Asia, where co-infection is reported to occur based on serologic evidence. We re-examined whether co-infection occurs by using a molecular approach. A duplex real-time polymerase chain reaction was developed that targeted a specific 16S ribosomal RNA gene of pathogenic Leptospira spp. and Orientia tsutsugamushi. Of 82 patients with an acute febrile illness who had dual infection on the basis of serologic tests, 5 (6%) had polymerase chain reaction results positive for both pathogens. We conclude that dual infection occurs, but that serologic tests may overestimate the frequency of co-infections. Copyright © 2013 by The American Society of Tropical Medicine and Hygiene.
ISSN: 00029637
Appears in Collections:Scopus 2011-2015

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