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Title: An evaluation of hepatitis B virus diagnostic methods and responses to antiretroviral therapy among HIV-infected women in Thailand
Authors: Philip James Peters
Janet M. McNicholl
Boonyos Raengsakulrach
Punneeporn Wasinrapee
Famui Mueanpai
Winai Ratanasuwan
Poj Intalapaporn
Jan Drobeniuc
Sumathi Ramachandran
Hong Thai
Guo Liang Xia
Saleem Kamili
Yury Khudyakov
Paul J. Weidle
Chong Gee Teo
Michelle S. McConnell
Centers for Disease Control and Prevention
Thailand Ministry of Public Health
Mahidol University
Rajavithi Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Sep-2013
Citation: Journal of the International Association of Providers of AIDS Care. Vol.12, No.5 (2013), 349-353
Abstract: Coinfection with HIV and hepatitis B virus (HBV) is common in resource-limited settings but is frequently not diagnosed. The authors retrospectively tested specimens for HBV in HIV-infected Thai women who had participated in an antiretroviral therapy (ART) clinical study. A substantial proportion (27 of 211; 13%) of HIV-infected women were HBV coinfected. Among HIV/HBV-coinfected women, the authors observed similar rates of antiretroviral-associated liver toxicity (despite nevirapine [NVP] use) and CD4 count reconstitution as observed in HIV-monoinfected women. Hepatitis B surface antigen (HBsAg) screening detected the majority (81%) of HBV coinfections, including all 5 HBV-coinfected women who did not suppress HBV despite 48 weeks of lamivudine (3TC)-containing ART and could be used to tailor ART for patients diagnosed with HBV coinfection in accordance with World Health Organization guidelines. Although HBsAg screening did not diagnose 5 occult HBV coinfections, these women achieved HBV suppression on 3TC-containing ART, suggesting that not detecting occult HBV coinfection would have limited clinical impact. © The Author(s) 2013.
ISSN: 23259582
Appears in Collections:Scopus 2011-2015

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