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Title: Comparative assessment of the intracellular survival of the Burkholderia pseudomallei bopC mutant
Authors: Varintip Srinon
Sunsiree Muangman
Nithima Imyaem
Veerachat Muangsombut
Natalie R. Lazar Adler
Edouard E. Galyov
Sunee Korbsrisate
Mahidol University
University of Leicester
Keywords: Immunology and Microbiology
Issue Date: 1-Aug-2013
Citation: Journal of Microbiology. Vol.51, No.4 (2013), 522-526
Abstract: Burkholderia pseudomallei, the causative agent of melioidosis, is a Gram-negative saprophytic bacterium capable of surviving within phagocytic cells. To assess the role of BopC (a type III secreted effector protein) in the pathogenesis of B. pseudomallei, a B. pseudomallei bopC mutant was used to infect J774A.1 macrophage-like cells. The bopC mutant showed significantly reduced intracellular survival in infected macrophages compared to wild-type B. pseudomallei. In addition, the bopC mutant displayed delayed escape from endocytic vesicles compared with the wild-type strain. This indicates that BopC is important, and at least in part, needed for intracellular survival of B. pseudomallei. © 2013 The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg.
ISSN: 19763794
Appears in Collections:Scopus 2011-2015

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