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Title: Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees
Authors: Pinghuang Liu
Nicole L. Yates
Xiaoying Shen
Mattia Bonsignori
M. Anthony Moody
Hua Xin Liao
Youyi Fong
S. Munir Alam
R. Glenn Overman
Thomas Denny
Guido Ferrari
Christina Ochsenbauer
John C. Kappes
Victoria R. Polonis
Punnee Pitisuttithum
Jaranit Kaewkungwal
Sorachai Nitayaphan
Supachai Rerks-Ngarm
David C. Montefiori
Peter Gilbert
Nelson L. Michael
Jerome H. Kim
Barton F. Haynes
Georgia D. Tomaras
Duke University
Fred Hutchinson Cancer Research Center
University of Alabama at Birmingham
Walter Reed Army Institute of Research
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Thailand Ministry of Public Health
Keywords: Immunology and Microbiology
Issue Date: 1-Jul-2013
Citation: Journal of Virology. Vol.87, No.14 (2013), 7828-7836
Abstract: The detailed examination of the antibody repertoire from RV144 provides a unique template for understanding potentially protective antibody functions. Some potential immune correlates of protection were untested in the correlates analyses due to inherent assay limitations, as well as the need to keep the correlates analysis focused on a limited number of endpoints to achieve statistical power. In an RV144 pilot study, we determined that RV144 vaccination elicited antibodies that could bind infectious virions (including the vaccine strains HIV-1 CM244 and HIV-1MNand an HIV-1 strain expressing transmitted/founder Env, B.WITO.c). Among vaccinees with the highest IgG binding antibody profile, the majority (78%) captured the infectious vaccine strain virus (CM244), while a smaller proportion of vaccinees (26%) captured HIV-1 transmitted/founder Env virus. We demonstrated that vaccine-elicited HIV-1 gp120 antibodies of multiple specificities (V3, V2, conformational C1, and gp120 conformational) mediated capture of infectious virions. Although capture of infectious HIV-1 correlated with other humoral immune responses, the extent of variation between these humoral responses and virion capture indicates that virion capture antibodies occupy unique immunological space. ©2013, American Society for Microbiology. All Rights Reserved.
ISSN: 10985514
Appears in Collections:Scopus 2011-2015

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