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Title: Analysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositis
Authors: Arada Rojana-Udomsart
Chalermchai Mitrpant
Ian James
Campbell Witt
Merrilee Needham
Timothy Day
Lynette Kiers
Alastair Corbett
Patricia Martinez
Steve D. Wilton
Frank L. Mastaglia
University of Western Australia
Yala Hospital
Mahidol University
Royal Perth Hospital
Royal North Shore Hospital
University of Sydney Faculty of Medicine
Royal Melbourne Hospital
University of Melbourne
Concord Repatriation General Hospital
Keywords: Immunology and Microbiology;Medicine;Neuroscience
Issue Date: 15-Jan-2013
Citation: Journal of Neuroimmunology. Vol.254, No.1-2 (2013), 174-177
Abstract: We compared the carriage frequencies of HLA-DRB3 and its major alleles and of HLA-DRB4 and HLA-DRB5 in an Australian sIBM cohort and a population control group who had previously been genotyped for the HLA-DRB1*03:01 risk allele. There was a strong disease association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01. The carriage of HLA-DRB4 was found to be strongly protective and abrogated the risk effect of HLA-DRB1*03:01. The findings indicate that haplotypic combinations of alleles at the HLA-DRB1 and secondary HLA-DRB loci have important risk modifying effects in sIBM. © 2012 Elsevier B.V.
ISSN: 18728421
Appears in Collections:Scopus 2011-2015

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