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Title: Polymorphisms in fas gene is associated with HIV-related lipoatrophy in thai patients
Authors: Sirirat Likanonsakul
Tippawan Rattanatham
Siriluk Feangvad
Sumonmal Uttayamakul
Wisit Prasithsirikul
Somkid Srisopha
Ravee Nitiyanontakij
Pimrapat Tengtrakulcharoen
MacIej Tarkowski
Agostino Riva
Emi E. Nakayama
Tatsuo Shioda
Thailand Ministry of Public Health
Mahidol University
Ospedale Luigi Sacco - Polo Universitario
Osaka University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-2013
Citation: AIDS Research and Human Retroviruses. Vol.29, No.1 (2013), 142-150
Abstract: The present study aimed to evaluate the role of genetic polymorphisms in the emergence of lipoatrophy or lipodystrophy in HIV-infected patients with antiretroviral therapy (ART) in Thailand. Position 455 upstream of the Apolipoprotein C3 gene (ApoC3 T-455C, rs2854116), codon 64 of the Beta3 adrenergic receptor gene (ARβ3 Tcod64C, rs4994), and position 670 upstream of the Fas gene (Fas A-670G, rs1800682) were genotyped in 829 HIV-infected Thai patients who had started ART. Crude and adjusted incidence rate ratios (IRR) were calculated using Poisson regression. The serum levels of cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were also analyzed. Multivariate analysis revealed an association between the Fas -670AA genotype, but not the ApoC3 -455 or ARβ3 cod64 genotypes, with the incidence of lipoatrophy after adjusting for gender and stavudine (d4T)-containing regimens (IRR=1.72, 95% CI=1.20-2.45, p=0.003). However, ApoC3 -455C homozygous patients showed elevated serum levels of triglycerides, while this genotype did not affect serum total cholesterol, HDL, or LDL levels in patients with lipoatrophy or lipodystrophy. In contrast, the ARβ3 cod64 genotype did not show any significant association with the serum levels of cholesterol, triglycerides, HDL, or LDL. In conclusion, Fas -670AA affected the incidence of lipoatrophy in HIV-1-infected Thai patients, while the ApoC3 -455C allele affected the serum levels of triglycerides. These results confirmed the role of genetics in the development of ART-related metabolic disorders. © Copyright 2013, Mary Ann Liebert, Inc. 2013.
ISSN: 19318405
Appears in Collections:Scopus 2011-2015

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