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Title: Dissemination of metallo-β-lactamase-producing Pseudomonas aeruginosa of sequence type 235 in Asian countries
Authors: Moon Jung Kim
Il Kwon Bae
Seok Hoon Jeong
So Hyun Kim
Jae Hoon Song
Jae Young Choi
Sang Sun Yoon
Visanu Thamlikitkul
Po Ren Hsueh
Rohani Md Yasin
M. K. Lalitha
Kyungwon Lee
Eulji University
Yonsei University College of Medicine
Asia Pacific Foundation for Infectious Diseases (APFID)
SungKyunKwan University, School of Medicine
Mahidol University
National Taiwan University Hospital
Institute for Medical Research Kuala Lumpur
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Dec-2013
Citation: Journal of Antimicrobial Chemotherapy. Vol.68, No.12 (2013), 2820-2824
Abstract: Objectives: To investigate the epidemiological traits of metallo-b-lactamase (MBL)-producing Pseudomonas aeruginosa (MPPA) clinical isolates collected by the Asian Network for Surveillance of Resistant Pathogens (ANSORP). Methods:Atotal of16MPPAclinical isolateswerecollected fromsix Asian countries in2000to2009byANSORP.The MBLgenewasdetected byPCRamplification. The genetic organization of the class1integroncarrying theMBLgene cassettewas investigated by PCR mapping and sequencing. Southern blotting, repetitive sequence-based PCR and multilocus sequence typing (MLST) experiments were performed to characterize the isolates. Results: PCR and sequencing experiments detected the blaVIM-2(n=12), blaVIM-3(n=1), blaIMP-6(n=2) and blaIMP-26(n=1) genes. The MBL genes were located on the chromosome in all isolates except one. Furthermore, all the MBL genes were located in a class 1 integron. All the MPPA isolates from Malaysia, Thailand, Sri Lanka and Korea were identified as sequence type (ST) 235 by MLST. Three VIM-2-producing isolates fromIndia were identified as ST773, and one isolate harbouring VIM-3 from Taiwan was identified as ST298. Conclusions: P. aeruginosa ST235might play a role in dissemination of MBL genes in Asian countries. © The Author 2013. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
ISSN: 14602091
Appears in Collections:Scopus 2011-2015

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