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Title: Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands
Authors: Dae Hun Kim
Ji Young Choi
Hae Won Kim
So Hyun Kim
Doo Ryeon Chung
Kyong Ran Peck
Visanu Thamlikitkul
Thomas Man Kit So
Rohani M.D. Yasin
Po Ren Hsueh
Celia C. Carlos
Li Yang Hsu
Latre Buntaran
M. K. Lalitha
Jae Hoon Song
Kwan Soo Ko
SungKyunKwan University, School of Medicine
Asia Pacific Foundation for Infectious Diseases (APFID)
Mahidol University
Princess Margaret Hospital Hong Kong
Institute for Medical Research Kuala Lumpur
National Taiwan University Hospital
National University Hospital, Singapore
Harapan Kita Cardiovascular Hospital
Department of Microbiology
SureCare Medical Centre
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Nov-2013
Citation: Antimicrobial Agents and Chemotherapy. Vol.57, No.11 (2013), 5239-5246
Abstract: In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaRtype resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenemresistant A. baumannii in Asia. Copyright © 2013, American Society for Microbiology. All Rights Reserved.
ISSN: 10986596
Appears in Collections:Scopus 2011-2015

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