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dc.contributor.authorThanyawan Pluemsamranen_US
dc.contributor.authorPinpat Tripataraen_US
dc.contributor.authorRattana Phadungrakwittayaen_US
dc.contributor.authorPravit Akarasereenonten_US
dc.contributor.authorTawee Laohapanden_US
dc.contributor.authorUraiwan Panichen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationEvidence-based Complementary and Alternative Medicine. Vol.2013, (2013)en_US
dc.description.abstractAyurved Siriraj HaRak (AVS022) formula has been used for topical remedy of dermatologic disorders. Oxidative stress induced by ultraviolet (UV) A irradiation could be implicated in photoaged skin through triggering matrix metalloproteinase-1 (MMP-1). We, therefore, explored the antioxidant mechanisms by which AVS022 formulation and its individual components protected against UVA-dependent MMP-1 upregulation in keratinocyte HaCaT cells. TLC analysis revealed the presence of multiple phenolics including gallic acid (GA) in the AVS022 extracts. We demonstrated that pretreatment with the whole formula and individual herbal components except T. triandra protected against increased MMP-1 activity in irradiated HaCaT cells. Moreover, all herbal extracts and GA, used as the reference compound, were able to reverse cytotoxicity, oxidant production, glutathione (GSH) loss, and inactivation of catalase and glutathione peroxidase (GPx). F. racemosa was observed to yield the strongest abilities to abolish UVA-mediated induction of MMP-1 and impairment of antioxidant defenses including GSH and catalase. Our observations suggest that upregulation of endogenous antioxidants could be the mechanisms by which AVS022 and its herbal components suppressed UVA-stimulated MMP-1 in HaCaT cells. In addition, pharmacological actions of AVS022 formula may be attributed to the antioxidant potential of its components, in particular F. racemosa, and several phenolics including GA. © 2013 Thanyawan Pluemsamran et al.en_US
dc.rightsMahidol Universityen_US
dc.titleRedox mechanisms of AVS022, an oriental polyherbal formula, and its component herbs in protection against induction of matrix metalloproteinase-1 in UVA-irradiated keratinocyte HaCaT cellsen_US
Appears in Collections:Scopus 2011-2015

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